Strange Mysteries of the Most Complicated Ethnopsychopharmacology

We are all holding.

—Terrance Mckenna

It’s not about regulated toxic drugs, but enjoyable drugs. You can buy such drugs as cyanid, DDT, types of herbicides and pesticides that will kill you in low doses, but yet the safest drugs known to man: psilocybin, DMT, LSD, is banned throughout most of the world. The number one mistake a parent can make is that they teach their kids all drugs are bad. So this kid grows up and one day decides to try pot, and you equalized that weed with all other drugs. Could other drugs be not as bad as well? Then they try stronger more potent drugs such as meth, cocaine, crack, heroin, etc., then you are hooked on these terrible spiritually, mentally, and physically robbing chemicals that is slowly and sometimes quickly killing you.

Journalists were the most responsible for making them illegal in the 60’s. They put out many articles revolving around the falsified information about how psychedelics change people. For example, they would say things like it makes people vicious serial killing psychopaths.

We’re going to look at some of the amazing benefits the most complicated chemical used in pharmacology today. That plant medicine of course is called ibogaine. It is found in Africa, extracted from the iboga plant, which has been used for millennia in that beautiful continent.

Ibogaine, when consumed, is broken down in the liver and gut wall into noribogaine (12-hydroxyibogamine). Ibogaine and noribogaine have similar properties, but noribogaine remains in the body longer. Both ibogaine and noribogaine readily cross the blood-brain barrier, and are in higher concentrations in the brain tissue compared to the bloodstream. It has one of the most complex pharmacology’s known to biochemists. There is absolutely nothing it doesn’t do.

You have the alpha 3 beta 4 nicotinic acetylcholine which is the target for Wellbutrin, which is responsible for the smoking sensation and anti-addictive effects. These receptors are part of the neuronal pathway that modulates the brain’s reward system. Because of this, they are involved in the mechanism of addiction. One study of 27 opioid addicts withdrawing from methadone, it is a opioid substitution therapy found that noribogaine was well tolerated, it moderately improved opioid withdrawal symptoms. Furthermore, numerous studies of animal models (such as rats and mice) have found that ibogaine exhibits anti-addictive properties against cocaine, morphine, amphetamine, alcohol, and nicotine.

Ibogaine blocks nicotinic acetylcholine receptors, thereby maintaining healthy levels of acetylcholine for longer periods of time. It also has an effect on the MNDA receptors similar to a ketamine effect. Ibogaine blocks NMDA receptors, which accounts for its hallucinogenic effects. It has a classical psychedelic effect with the 5HT2A receptors, it’s a dopamine re-uptake inhibitor, it has the same effects on dopamine transporters resulting in higher dopamine levels. Dopamine levels in addicted individuals are altered due to the excessive use of abused drugs, such as cocaine. Purified ibogaine hydrochloride was marketed under the name Lambarene in France (1939-1970) as an antidepressant and stimulator of mental state.  Ibogaine can reset the dopamine levels to pre-addiction levels. It is a serotonin re-uptake inhibitor, it releases this protein GDNF which is one of the most important treatment in Parkinson’s disease — it’s one of the only things proven to regrow dopaminergic neurons.

Ibogaine has antimicrobial properties, studies done with mice showed that iboga alkaloids reduced the number of deaths caused by Candida albicans infections. Ibogaine inhibits the activity of enzymes called lipases, which are used by Candida albicans to infect human cells. Therefore, when combined with a commonly used antibiotic, it suppressed fungus development. Additionally, ibogaine has antimycobacterial activity, as shown by the reduction of bacterial cultures of several pathogenic microorganisms. Experiments conducted on human blood cells showed that ibogaine interrupts the replication of retroviruses (such as HIV–1), and blocks the infection process. It is also used in Africa to cure HPV.

Ibogaine acts as an antioxidant, it increases the activity of antioxidant enzymes (SOD1) in human red blood cells. 

In observational trials, ibogaine improved symptoms of depression, anxiety, and obsessive-compulsive disorder for an extended period of time after ibogaine treatment. 

Synthetic iboga alkaloids have been proposed as a treatment for obesity in rats. Chronic administration of this substance in rats prevented increases in body weight, decreased fat deposition, and reduced sugar consumption.

Ibogaine has anticancer properties In the lab, ibogaine reversed multi drug resistance in human cancer cells.




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